Oak Brook, IL – The June issue of SLAS technology is a special edition entitled “Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine”. Free online access to the articles in this collection is provided courtesy of Corning Life Sciences, the issue sponsor.
Precision medicine is becoming more and more popular and effective for the targeted treatment and treatment of human diseases. Cell models derived from patients led to high throughput screenings (HTS) in laboratory automation. While the maintenance and expansion of cells for HTS is mostly manual, this special edition explores an automated way for HTS in research settings that takes cell expansion into account. This design is flexible for research and development of different cell types. The June issue analyzes protocols for the controlled cell seeding, splitting and expansion of human fibroblasts, induced pluripotent stem cells (iPSCs) and neural progenitor cells (NPCs). These multiple platforms are well suited for research on patient-based cell models for precision medicine. “Significant improvements have been made in the formation of complex 3D structures, but automating assay protocols with these models remains challenges. The flowchips described in the issue contain protected sample chambers to enable media exchange, sample staining, washing steps and sampling of supernatants. “Without interruption or loss of the 3D sample,” says SLAS technology Author Evan F. Cromwell, Ph.D. (Protein Fluidics, Inc.).
The June issue of SLAS technology contains six original research articles including:
- Toxicity of combinations of kinase pathway inhibitors to normal human cells in a three-dimensional culture
- Spheroid trapping and calcium spike estimation techniques to automate 3D culture
- Miniaturized drug susceptibility and resistance test on patient-derived cells with droplet microarray
- Automation of human-induced pluripotent stem cell culture and differentiation of iPSC-derived retinal pigment epithelium for personalized drug testing
- Create an affordable, easy-to-use electronic inventory system for laboratory samples
- Adaptation of an inexpensive and open source commercial pipetting robot 311 for nanoliter liquid handling
Other articles are:
- Disease modeling with cell-based 3D assays using a novel flowchip system and high-content imaging
- Three-dimensional macroporous sponge for culture of patient-derived xenograft organoids of hepatocellular carcinoma
- Automated device for opening bioanalytical sample tubes of various sizes to reduce the burden on the technician and increase productivity
- Literature Highlights Column: Discoveries and Technology Highlights in the Life Sciences
Access to June SLAS technology Edition is available at https: /
SLAS (Society for Laboratory Automation and Screening) is an international specialist society of scientists, industry and government life science researchers, as well as developers and providers of laboratory automation technology. SLAS ‘mission is to bring together researchers from academia, industry and government to advance life sciences discovery and technology through education, knowledge sharing and global community building.
SLAS Discovery: Advancing the science of drug discovery, 2019 impact factor 2.195. Editor-in-Chief Robert M. Campbell, Ph.D., Twentyeight-Seven Therapeutics, Boston, MA (USA).
SLAS technology: translation of life science innovations, 2019 impact factor 2.174. Editor-in-chief Edward Kai-Hua Chow, Ph.D., National University of Singapore (Singapore).
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